A REVIEW OF PKRRATING

The activated enzyme then phosphorylates its important substrate, the translational initiation variable eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs to some conserved family of 4 protein kinases (PKR, PERK, GCN2, HRI) that all phosphorylate eIF2α in reaction to diverse stimuli12, triggering the built-in tension re